{
  "schema": "vedokrok.public-item.v1",
  "release_id": "MHC-RPUB-20261011-9e4b62c5",
  "url": "/knowledge/separate-being-offered-a-programme-from-completing-it",
  "id": "MHC-D-RESEARCH-0057",
  "version": "0.1.0",
  "title": "Separate being offered a programme from completing it",
  "summary": "Assignment and perfect attendance are not the same intervention question.",
  "kind": "concept",
  "body": "An assignment-based analysis asks about the effect of allocation. An adherence-focused analysis asks something different and needs methods that address selection. Read the actual inclusions, not only the label beside the table.",
  "limits": [
    "Do not assume every intention-to-treat label guarantees complete data, or every adherence analysis is invalid."
  ],
  "topics": [],
  "intents": [
    "understand-a-decision"
  ],
  "source_ids": [
    "cochrane-trial-bias"
  ],
  "evidence": [
    {
      "claim": "Assignment effects and adherence effects are different questions; naive per-protocol exclusions can introduce bias.",
      "source_id": "cochrane-trial-bias",
      "role": "supports",
      "note": "Claim basis: technical_definition. Claim limit: The label intention-to-treat does not itself establish how missing data were handled.\nSource access: selected_html_passages; accessed on: 2026-09-17; inspected sections: [\"8.2.2\", \"8.2.3 signalling questions\", \"8.3\", \"8.5\", \"8.6\"].\nSource note: The elements introduce questions for readers; they do not reproduce or claim to complete the RoB 2 assessment.\nAgent scope review, 2026-10-11: Cochrane 8.2.2/8.5 separate assignment and adherence questions. Naive exclusions can bias a comparison; the ITT label alone does not settle missing-data handling.",
      "locator": "8.2.2; 8.5"
    }
  ],
  "use_when": [
    "A trial's result is being interpreted without checking which analysis population it uses."
  ],
  "avoid_when": [
    "Do not assume every intention-to-treat label guarantees complete data, or every adherence analysis is invalid."
  ],
  "example": "A training provider removes everyone who missed sessions before comparing results. The remaining participants may differ in more than their exposure to the lessons.",
  "check": "Can you explain who remained in each analysed group and why?",
  "published_at": "2026-10-11T18:15:00Z",
  "review": {
    "kind": "agent",
    "label": "Agent editorial and scoped evidence review",
    "reviewed_at": "2026-10-11T18:12:50Z"
  },
  "editorial_overlay": null,
  "editorial": null,
  "notices": [],
  "sources": [
    {
      "id": "cochrane-trial-bias",
      "title": "Chapter 8: Assessing risk of bias in a randomized trial",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08"
    }
  ],
  "relations": [],
  "collections": [
    {
      "id": "RC-D4FD0B28897E9517",
      "title": "Check what a study can actually tell you",
      "url": "/collections/check-what-a-study-can-actually-tell-you"
    }
  ],
  "topic_hubs": [],
  "solution_packs": []
}